A study by researchers from the National University of Singapore (NUS), found that with the progress of the day the electrical activity between different brain regions may significantly decrease. Researchers have suggested that the excitation could be the lowest in the morning, increases in the mid-afternoon, and dips in the early evening.<br />” <br />”The study, published in the journal PLOS, revealed a cumulative decrease in the excitation between different regions of resting brains as the day progressed. It said this global decrease is most prominent in brain regions responsible for processing vision and body movements.<br />” In the study, they have analysed the brain scan data of approximately 900 subjects who were examined between 8 AM and 10 PM on two different days.<br />” <br />” &nbsp;The scientists have found that across the whole brain the time of day is also associated with marked decreases in resting-state functional connectivity.&nbsp; Csaba Orban, first author of the study from NUS has said researchers have also observed slight time-of-day-associated variation in the breathing patterns of participants. This suggests that researchers may also need to consider clues outside of the brain to fully understand the effects.<br />”<br />”Thomas Yeo, senior author of the study from NUS said these findings will motivate fellow neuro-scientists to give more consideration to potential effects of time of day on measures of brain activity, especially in other large-scale studies where subjects are often scanned throughout the day for logistical reasons.<br />