Olympic medalists P V Sindhu and Saina Nehwal lock horns in the opening match between defending champions Chennai Smashers and Awadhe Warriors at the third edition of the Premier Badminton League in Guwahati today.Sindhu, currently ranked No 3 in the World, holds a 2-1 edge in her recent meetings against Saina, with her only loss coming in a riveting Senior National Championship finale held at Nagpur last month.