The Bombay Stock Exchange benchmark Sensex lost 50 points to 20,106 in the opening trade today on profit-booking. The Sensex later made some gains and was trading at 20,210, up by over 53 points. In other Asian markets, the Hong Kong's Hang Seng index was quoting higher by 0.52 per cent, while Japanese Nikkei was marginally up by 0.59 per cent in the morning trade.