Scientists at the CSIR-Centre for Cellular and Molecular Biology (CCMB) in Hyderabad have demonstrated the role of a protein secretagogin (SCGN) in increasing insulin action in obesity-induced diabetes.<br />” <br />” CCMB said that the findings established SCGN as a functional insulin-binding protein with therapeutic potential against diabetes.<br />” <br />” They show that SCGN binds to insulin and protects it from various stresses, increases its stability and adds to its action.<br />” <br />” It said various kinds of cellular stresses can result in loss of structure and function of insulin, ultimately leading to diabetes.<br />” <br />” At present, the processes regulating insulin synthesis, maturation, secretion and signalling in diabetes were not completely understood.<br />” <br />” Yogendra Sharma from CCMB and his colleagues Anand Sharma, Radhika Khandelwal and Amrutha Chidananda have<br />” demonstrated the role of a protein secretagogin (SCGN) in increasing insulin action in obesity-induced diabetes.<br />” <br />” The scientists have shown injection of SCGN (found at lower levels in diabetic patients) in obese diabetic mice clears excess insulin from circulation and reduces fat mass.<br />” <br />” CCMB release said that SCGN treated animals also had lower levels of harmful<br />” LDL-cholesterol and lower lipid accumulation in liver cells.<br />” <br />” These findings were published in the latest issue of the journal iScience.<br />” <br />” Diabetes and neurodegenerative disorders such as dementia and Alzheimer's disease are often linked with each other.<br />” <br />” SCGN is found in lower quantities in the brains of Alzheimer's patients.<br />” &nbsp; &nbsp;<br />” The Researchers said that SCGN would soon become a diagnostic marker, and one should check its potential in diabetes management.<br />” &nbsp;<br />