At least two persons were killed and about 450 injured overnight when police baton-charged hundreds of anti-government protesters led by Imran Khan and Tahir-ul-Qadri who marched towards Prime Minister Nawaz Sharif's residence in Islamabad demanding his resignation. The clashes started after Tehrik-e-Insaf Chief Imran Khan and Awami Tehrik chief Qadri yesterday ordered their hundreds of supporters to shift the protest venue in the front of the residence of Prime Minister Sharif to force him to quit.

Police fired tear gas shells and rubber bullets to disperse the protesters outside the prime minister's official residence and the adjacent parliament building. Hundreds of protesters entered the lawn of parliament but they were pushed back at the main entrance of the building where army was deployed. Prime Minister Sharif left for Lahore. A late night government announcement categorically ruled out Sharif's resignation.

Meanwhile, fearing backlash from anti-government protesters, roads leading to Prime Minister Nawaz Sharif's Lahore residence, where he is currently residing, have been blocked and heavy contingent of police deployed. The Lahore police in wee hours of today placed containers on Raiwind Road leading to the palatial Jati Umera residence of Prime Minister Sharif.

A source in the ruling PML-N said, Sharif had left the prime minister house in Islamabad for his Lahore residence along with his personal staff fearing it might come under siege from the protesters. His brother and Punjab Chief Minister Shahbaz Sharif is also living there.

The source said, Sharif will not move to the prime minister house in Islamabad till the police manage to clear the area from Khan'sPakistan Tahreek-i-Insaf and Qadri's Pakistan Awami Tahreek.